Begoña Díaz Laboratory
Tagline:The Lundquist Institute at Harbor-UCLA Medical Center
Torrance, Los Angeles, CA, USA
About me
The Díaz Lab at the Lundquist Institute investigates the biology of normal and tumor cells to advance knowledge on mechanisms of cell invasion and organelle adaptation to stress. Our goal is to find novel interventions that can provide clinical solutions to human conditions such as chronic wounds, lung interstitial diseases and lung cancer.
Cell invasion and organelle adaptation to stress
- Invadopodia function and regulation
- Adaptation of lysosomes and mitochondria to stress
- Protein myristoylation and tumor biology
Publications
N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Journal ArticlePublisher:Cancer Research CommunicationsDate:2024Authors:Sofia GeroyskaIsabel MejiaAlfred A ChanMarian NavarreteVijaya PandeySamuel KharpatinJuliana NogutiFeng WangDaniel SroleTsui-Fen ChouJames WohlschlegelElizabeta NemethRobert DamoiseauxDavid B ShackelfordDelphine J LeeBegoña DíazDescription:https://aacrjournals.org/cancerrescommun/article/4/7/1815/746692
TKS5-positive invadopodia-like structures in human tumor surgical specimens
Journal ArticlePublisher:Experimental and molecular pathologyDate:2019Authors:Yu-Chuan ChenMatthew BaikJoshua T ByersKathryn T ChenSamuel W FrenchBegoña Díaz
Analysis of Golgi Morphology Using Immunofluorescence and CellProfiler Software
Book ChapterPublisher: Methods in Molecular Biology, Springer NatureDate:2022Authors:Isabel MejiaYu-Chuan ChenBegoña DíazAdaptation of the Golgi apparatus in cancer cell invasion and metastasis
ReviewPublisher:Frontiers in cell and developmental biologyDate:2021Authors:Sarah BuiIsabel MejiaBegoña DíazYanzhuang WangN-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells
Journal ArticlePublisher:Scientific ReportsDate:2020Authors:Yu-Chuan ChenMarian S NavarreteYing WangNatalie C McClintockReiko SakuraiFeng WangKathryn T ChenTsui-Fen ChouVirender K RehanDelphine J LeeBegoña DiazPancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
Journal ArticlePublisher:BiomedicinesDate:2020Authors:Isabel MejiaSandhya BodapatiKathryn T ChenBegoña DíazExperimental supporting data on TKS5 and cortactin expression and localization in human pancreatic cancer cells and tumors
Journal ArticlePublisher:Data in brief, ElsevierDate:2019Authors:Yu-Chuan ChenMatthew BaikJoshua T ByersKathryn T ChenSamuel W FrenchBegoña DíazIdentification of invadopodia by TKS5 staining in human cancer lines and patient tumor samples
Journal ArticlePublisher:MethodsX, ElsevierDate:2019Authors:Matthew BaikBarbara FrenchYu-Chuan ChenJoshua T ByersKathryn T ChenSamuel W FrenchBegoña Díaz
Current & Former Lab Members
Description:
Lia Osipyan, Sofia Geroyska, Lucy Weaver, Aakash Kondaka, Isabel Mejia, Abbie Maemoto, Matthew Baik, Malek Chamas & Yu-Chuan (Patrick) Chen
